| Trade Name | Generic Name | Most Common Use | Possible Side Effects* Side effects listed are only partial. See your physician for the full list of possible side (May require adjustment of drug dosage) | Serious Side Effects* Side effects listed are only partial. See your physician for the full list of possible side (Usually requires discontinuation of the drug) | Manufacterer |
| Aptiom ® | Eslicarbazepine Acetate | Partial onset seizures in patients 4 years+ | risk of suicidal thoughts or behavior, dizziness, disturbance of normal gait and coordination, confusion | dermatologic reactions, any listed, rare: anaphylaxis | Sunovion Pharmaceuticals |
| Banzel ® | rufinamide | Lennox Gasteau; used as an add-on medication | suicidal thoughts, depression, change in moods/behavior, aggression, anger, anxiety, restlessness, panic, and trouble sleeping | any listed | Eisai Pharmaceuticals |
| Briviact® | brivaracetam | partial-onset focal seizures; ages 1 month+ | suicidal behavior, fatigue, dizziness, disturbance in gait and coordination | psychiatric adverse reactions, neurological reactions | UCB, Inc. |
| Carbatrol ® | carbamazepine; carbamazepine XR | complex partial (psychomotor or temporal lobe), generalized tonic-clinic (grand mal) | drowsiness, dizziness, nausea & vomiting | allergic reaction, impaired liver function | Apotex, Inc. |
| Tegretol ® | carbamazepine | simple partial | blurred vision, double vision, lethargy | bone marrow suppression, birth defects, Stevens-Johnson Syndrome (life-threatening rash), arrhythmia, seizures | Upsher-Smith |
| Tegretol XR ® | carbamazepine - extended release | simple partial | nausea, vomiting, unsteadiness | bone marrow suppression, birth defects, Stevens-Johnson Syndrome (life-threatening rash), arrhythmia seizures | Upsher-Smith |
| Depakote ® | divalproex sodium | absence (petit mal), generalized tonic-clonic (grand mal) | nausea, vomiting, indigestion | allergic reaction, impaired liver function | AbbVie, Inc. |
| Depakene ® | valproic acid | complex partial, simple partial | sedation, dizziness, tremor, hair loss, liver function change, weight gain or loss, menstrual irregularities, fluid retention | bone marrow suppression, pancreatitis, bleeding, Stevens-Johnson Syndrome; Should not take while pregnant | AbbVie, Inc. |
| Dilantin ® | phenytoin | generalized tonic-clonic; partial seizures | body hair increase, gum overgrowth, tremor, anemia, loss of coordination, double vission, nausea, confusion, slurred speach, acne | allergic reaction, impaired liver function, lymphoma, Purple Glove Syndrome, cardiovascular collapse, tissue necrosis, arrhythmia, bone marrow suppression, SLE (Systematic Lups Eryth) | Viatris |
| Diacomi® | stiripentol | Biocodex, Inc. | |||
| Diastat ® | diazepam (see also Valtoco & Nayzilam) | temporary add on therapy for | sleepiness, dizziness | possible drug interactions that can be serious | Baush Health, Valeant Pharmaceuticals |
| AcuDial™ | diazepam (see also Valtoco & Nayzilam) | temporary add on therapy for | sleepiness, dizziness | possible drug interactions that can be serious | Baush Health, Valeant Pharmaceuticals |
| Valtoco® | diazepam nasal spray, replaces Diastat 12+ yrs | controlling prolonged seizures | dizziness, headache | Neurelis | |
| Epidolex® | Cannabidiol oral solution | Lennox Gasteaux syndrome; Dravet syndrome (patient 2 yrs and older) | loss of appetite, nausea, vomiting, fever, feeling unwell, unusual tiredness, yellowing of the skin or the whites of the eyes (jaundice); itching, unusual darkening of the urine | may cause liver problems | Jazz Pharmaceuticals |
| Fintepla® | finfluramine | Dravet & LGS | decreased appetite and weight, sleepiness, lethargy | shortness of breath, weakness, lightheadedness or fainting, swollen ankles or feet, suicidal thoughts, insomnia, irritability, depression, aggression or violence | Zogenix |
| Felbatol ® | felbamate | generalized tonic-clonic, complex partial, secondary generalized (Lennox-Gastaut Sydrome) | insomnia pain or discomfort, nausea, loss of appetite, hives, swelling of the face and throat, fever, skin rash | allergic reaction, bone marrow suppression, liver failure, difficulty breathing | MedPointe |
| Fycompa® | perampanel | partial-onset; generalized tonic-clonic; simple partial and complex partial | risk of suicidal thoughts or behavior, dizziness, disturbance of normal gait and coordination, confusion | serious psychiatric and behavioral reactions | Eisai |
| Gabitril ® | tigabine HCI | partial seizures, secondary generalized | dizziness, anthemia, somnolence, nausea, vomiting, nervous impaired memory | allergic reaction, central nervous system, depression, seizures | McGuff |
| Keppra ® | levetiracetam | add on therapy for partial seizures | drowsiness, behavioral/mood disorders, headache, loss of coordination | UCB, Inc. | |
| Klonopin ® | clonazepam | atonic, myoclonic | lethargy, dizziness, behavioral changes, increase in salvation, increase in bronchial secretions, clumsiness, | allergic reaction, respiratory reaction, depression, impaired liver function, seizures | Teva |
| Lamictal ® | lamotrigine | partial seizures, generalized seizures, secondary generalized (Lennox Gastaut) | nausea, dizziness, loss of coordination, rash, headache | allergic reaction, hepatic failure, bone marrow suppression, Stevens-Johnson Syndrome | GlaxoSmithKline |
| Ativan ® | lorazepam | anxiety, sleeping problems | drowsiness, dizziness, weakness, dry mouth, diarrhea, nausea, change in appetite | shaking, muscle twitching, changes in mental health, difficulty concentration, shaking | Mylan |
| Lyrica ® | pregbalin | nerve damage due to diabetes, shingles or spinal cord injury, also used to treat epilepsy and anxiety | blurred/double vision, clumsiness, dizziness, trouble thinking | infection, decreased blood platelets, puffy face | Pfizer |
| Mysoline ® | primidone | complex partial (psychomotor or temporal lobe), generalized tonic-clonic (grand mal), simple partial | drowsiness, loss of appetite, irritablitiy, nausea, vomiting, dizziness, loss of coordination | allergic reaction, impaired liver function, dyspnea (shortness of breath) lupus-like symptoms | Bausch Health Companies, Inc. |
| Nayzilam® | midazolam | short term treatment for cluster seizures, ages 12+, rescue med | drowsiness, headache, nasal discomfort, throat irritation, runny nose | shallow or slowed breathing, breathing stops, excessive sleepiness | UCB |
| Neurontin ® | gabapentin | add-on therapy for partial and generalized seizures | nausea, drowsiness, weight gain, dizziness, involuntary eye movement | leukopenia (low white blood cell count) | Pfizer |
| Onfi ® (largely available as generic only) | clobazam | Lennox-Gastaut syndrome | confusion, hallucinations, fever, cough with yellow or green mucus, feeling short of breath, severe drowsiness, feeling like you moght pass out, weak or shallow breathing, pain or burning when you urinate, urination less than usual or not at all | feelings of suicide | Lundbeck |
| No Trade Name | phenobarbital | most types of seizures | irritability, dizziness, lethargy, hyperactivity, loss of coordination, loss of appetite | allergic reaction, Stevens-Johnson Syndrome, TTP (abnormality of blood cells), respiratory depression, bone marrow suppression, angio edema | multiple companies |
| Sabril ® | topiramate | add on therapy for partial seizures in adults | blurred vision, confusion, drowsiness, nausea, vomiting, kidney stones, dizziness, loss of coordination, glaucoma | allergic reaction, birth defects, nephrolithiasis | Johnson & Johnson - subsidiary of Janssen Pharmaceuticals |
| Qudexy XR ® | topiramate | add on therapy for partial seizures in adults | blurred vision, confusion, drowsiness, nausea, vomiting, kidney stones, dizziness, loss of coordination, glaucoma | allergic reaction, birth defects, nephrolithiasis | Johnson & Johnson - subsidiary of Janssen Pharmaceuticals |
| Trokendi XR ® | topiramate | add on therapy for partial seizures in adults | blurred vision, confusion, drowsiness, nausea, vomiting, kidney stones, dizziness, loss of coordination, glaucoma | allergic reaction, birth defects, nephrolithiasis | Johnson & Johnson - subsidiary of Janssen Pharmaceuticals |
| Tranxene ® | clorazepate, dipotassium | complex partial (psychomotor or temporal lobe) | drowsiness, dizziness | allergic reaction, impaired liver function | Recordati Rare Diseases, Inc., Lundbeck Pharmaceuticals |
| Trileptal ® | oxcarbazepine | complex partial (psychomotor or temporal lobe), generalized tonic-clonic (grand mal), simple partial | drowsiness, dizziness, blurred vision, double vision, lethargy, nausea, vomiting, unsteadiness | allergic reaction, impaired liver function, bone marrow suppression, hyponatraemia, birth defects, Stevens-Johnson Syndrom, angio edema | Camber Pharmaceuticals |
| Vimpat®, UCB Pharmaceuticals now mostly available as generic only | lacosamide | UCB is the manufacturer of the Brand name Vimpat ®; generic brands are made by several companies | |||
| Xcopri | Cenobamate | focal aware, or simple partial seizure | feeling sleepy or tired, dizziness, double vision, headahce | suicidal thoughts and behavior, multiorgan hypersensitivity, QT shortening | SK Life Science |
| Zarontin ® | ethosuximide | absence (petit mal) | drowsiness, hyperactivity, nausea, vomiting, sleep disturbance | allergic reaction, impaired liver function, SLE (Systemic Lupus Eryth), Stevens-Johnson Syndrome, bone marrow suppression | Pfizer |
| Zonegran ® | zonisamide | add on therapy for partial, secondary generalized, and tonic-clonic seizures | anorexia, dizziness, fatigue, confusion, irritability, kidney stones | allergic reaction, Stevens-Johnson Syndrome, heat stroke, withdrawal seizures, bone marrow suppression, anaphylaxis | Elan Corporation |
| This list may not be a complete list of side effects; please consult your physician for full disclosure. |
